Can-Fite BioPharma
AboutSciencePipelineInvestor InformationContact Us

Pipeline

Pipeline

Overview
CF101
CF102
CF602
 

CF102

Drug Product
CF102CF102 is an oral small molecule drug generically known as Cl-IB-MECA (2-chloro-N6-(3-iodobenzyl)-adenosine-5’- N-methyl-uronamide), a highly specific and selective agonist at the A3 adenosine receptor (A3AR):

Preclinical Pharmacology
CF102 has potent anti-cancer effect, particularly against hepatocellular carcinoma, and anti-inflammatory activity demonstrated in pre-clinical animal models of liver inflammation.

Mechanism of Action
CF102 mechanism of action is mediated via de-regulation of the NF-κB and the Wnt signal transduction pathways, resulting in apoptosis of tumor cells. The protective effect of CF102 is mediated via down-regulation of the NF-κB signal transduction pathway and preventing apoptosis.

Safety
The safety of CF102 has been demonstrated in preclinical studies, Phase I clinical study and in human Phase I/II clinical studies demonstrating a favorable safety profile.

Efficacy
Phase I/II study in hepatocellular carcinoma (HCC) successfully met its primary and secondary endpoints demonstrating initial indications for efficacy of CF102. A global Phase II study treating patients with CF102 as a second line therapy will start enroling patients shortly.